Research: Comorbidities and Late Outcomes in Neonatal Pulmonary Hypertension

Clin Perinatol

. 2024 Mar;51(1):271-289.

 doi: 10.1016/j.clp.2023.10.002. Epub 2023 Nov 7.

Comorbidities and Late Outcomes in Neonatal Pulmonary Hypertension

Emily S Stieren 1Deepika Sankaran 2Satyan Lakshminrusimha 2Catherine A Rottkamp 2

Affiliations expand


Long-term outcomes of persistent pulmonary hypertension of newborn (PPHN) depend on disease severity, duration of ventilation, and associated anomalies. Congenital diaphragmatic hernia survivors may have respiratory morbidities and developmental delay. The presence of PPHN is associated with increased mortality in hypoxic-ischemic encephalopathy, though the effects on neurodevelopment are less clear. Preterm infants can develop pulmonary hypertension (PH) early in the postnatal course or later in the setting of bronchopulmonary dysplasia (BPD). BPD-PH is associated with higher mortality, particularly within the first year. Evidence suggests that both early and late PH in preterm infants are associated with neurodevelopmental impairment.

Keywords: Bronchopulmonary dysplasia; Congenital diaphragmatic hernia; Extracorporeal membrane oxygenation; Hearing loss; Hypoxic-ischemic encephalopathy; Neurodevelopmental outcomes; Nitric oxide.

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