Research: Congenital diaphragmatic hernia-associated cardiac dysfunction.

Semin Perinatol. 2019 Jul 30. pii: S0146-0005(19)30102-8. doi: 10.1053/j.semperi.2019.07.007. [Epub ahead of print]

Congenital diaphragmatic hernia-associated cardiac dysfunction.

Patel N1Massolo AC2Kipfmueller F3.

Author information

1Department of Neonatology, Royal Hospital for Children, 1345 Govan Road, Glasgow G51 4TF, UK. Electronic address: of Medical and Surgical Neonatology, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy.3Department of Neonatology and Pediatric Critical Care Medicine, University of Bonn, Bonn, Germany.


There is increasing evidence that cardiac dysfunction is a key contributor to CDH pathophysiology. Dysfunction in both right and left ventricles is common in the early neonatal period, contributes to clinical disease severity, and is associated with adverse outcomes including death and ECMO use. Early and routine assessment of ventricular function and pulmonary artery pressure may guide individualized clinical decision-making, including use of pulmonary vasodilators, cardiotropes, ECMO, and timing of surgical repair. Minimizing cardiac dysfunction, whether by prenatal, postnatal or perinatal treatment strategies, may lead to improved outcome in CDH.

Copyright © 2019 Elsevier Inc. All rights reserved.


Cardiac function; Congenital diaphragmatic hernia; Echocardiography; Pulmonary hypertension; Ventricular functionPMID: 31420110 DOI: 10.1053/j.semperi.2019.07.007

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