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Research: Neonates With Complex Cardiac Malformation and Congenital Diaphragmatic Hernia Born to SARS-CoV-2 Positive Women-A Single Center Experience

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Research: Neonates With Complex Cardiac Malformation and Congenital Diaphragmatic Hernia Born to SARS-CoV-2 Positive Women-A Single Center Experience

World J Pediatr Congenit Heart Surg

. 2020 Aug 27;2150135120950256. doi: 10.1177/2150135120950256. Online ahead of print.https://pubmed.ncbi.nlm.nih.gov/32851931/

Neonates With Complex Cardiac Malformation and Congenital Diaphragmatic Hernia Born to SARS-CoV-2 Positive Women-A Single Center Experience

Nimrod Goldshtrom 1Diana Vargas 1Angelica Vasquez 1Faith Kim 1Kinjal Desai 1Mariel E Turner 1Oliver Barry 1Alejandro Torres 1Stéphanie Levasseur 1Svetlana Strletsova 2Palka R Gupta 2Jennifer R Defazio 3Vincent Duron 3William Middlesworth 3Lisa Saiman 1 4Russell Miller 5Dena Goffman 5Emile A Bacha 3David Kalfa 3Damien J LaPar 3Ganga Krishnamurthy 1Affiliations expand

Abstract

Background: Our understanding of the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on pregnancies and perinatal outcomes is limited. The clinical course of neonates born to women who acquired coronavirus disease 2019 (COVID-19) during their pregnancy has been previously described. However, the course of neonates born with complex congenital malformations during the COVID-19 pandemic is not known.

Methods: We report a case series of seven neonates with congenital heart and lung malformations born to women who tested positive for SARS-CoV-2 during their pregnancy at a single academic medical center in New York City.

Results: Six infants had congenital heart disease and one was diagnosed with congenital diaphragmatic hernia. In all seven infants, the clinical course was as expected for the congenital lesion. None of the seven exhibited symptoms generally associated with COVID-19. None of the infants in our case series tested positive by nasopharyngeal test for SARS-CoV-2 at 24 hours of life and at multiple points during their hospital course.

Conclusions: In this case series, maternal infection with SARS-CoV-2 during pregnancy did not result in adverse outcomes in neonates with complex heart or lung malformations. Neither vertical nor horizontal transmission of SARS-CoV-2 was noted.

Keywords: COVID-19; SARS-CoV-2; congenital heart disease; neonate; vertical transmission.

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