Research: Survival trends and outcomes among preterm infants with congenital diaphragmatic hernia.

J Perinatol. 2019 Oct 17. doi: 10.1038/s41372-019-0523-6. [Epub ahead of print]

Survival trends and outcomes among preterm infants with congenital diaphragmatic hernia.

Peluso AM1Othman HF2Elsamny EM2Sammour I2Yeaney NK2Aly H2.

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The objective of this study was to use current national data to evaluate the characteristics and survival trends of preterm infants born with CDH from 2004 to 2014.


Data was queried from the National Inpatient Sample (NIS) and KID database from 2004 to 2014. Infants were included if diagnosed with CDH by ICD-9 coding and gestational age <37 weeks. Descriptive statistics, chi-square, and trend analysis were completed.


We identified 2356 infants born prematurely with CDH. The overall survival rate was 49%. The survival range is 21.2-62.3% for gestational age <26 weeks to 35-36 weeks, respectively. Total mortality was 1183; of them, 1052 (89%) were not repaired and 363 (30.7%) did not receive mechanical ventilation. Surgical repair occurred in 55.1% of infants.


Preterm infants have lower survival compared with term infants. Survival rates decrease with lower gestational age and have improved over time.PMID: 31624324 DOI: 10.1038/s41372-019-0523-6

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