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Research: Global gene expression profiling in congenital diaphragmatic hernia (CDH) patients

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Research: Global gene expression profiling in congenital diaphragmatic hernia (CDH) patients

Funct Integr Genomics

. 2022 Mar 9. doi: 10.1007/s10142-022-00837-9. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/35260975/

Global gene expression profiling in congenital diaphragmatic hernia (CDH) patients

Kubilay Gürünlüoğlu 1Muhammed Dündar 2Turgay Unver 3Necmettin Akpınar 1Ismail Kürşad Gokce 4Semra Gürünlüoğlu 5Mehmet Demircan 1Ahmet Koc 6Affiliations expand

Abstract

Congenital diaphragmatic hernia (CDH) is an anomaly characterized by a defect in the diaphragm, leading to the passage of intra-abdominal organs into the thoracic cavity. Herein, the presented work analyzes the global gene expression profiles in nine CDH and one healthy newborn. All of the patients had left posterolateral (Bochdalek) diaphragmatic hernia, operated via an abdominal approach, and stomach and bowels in the thorax cavity. Some patients also had additional anomalies. A total of 560 differentially regulated genes were measured. Among them, 11 genes showed significant changes in expression associated with lung tissue, vascular structure development, and vitamin A metabolism, which are typical ontologies related to CDH etiology. Among them, SLC25A24 and RAB3IL1 are involved in angiogenesis, HIF1A and FOXC2-AS1 are related with the alveolus, MAGI2-AS3 is associated with the diaphragm, LHX4 and DHH are linked with the lung, and BRINP1, FZD9, WNT4, and BLOC1S1-RDH5 are involved in retinol. Besides, the expression levels of some previously claimed genes with CDH etiology also showed diverse expression patterns in different patients. All these indicated that CDH is a complex, multigenic anomaly, requiring holistic approaches for its elucidation.

Keywords: Congenital diaphragmatic hernia; Global transcriptome; Multigenic; Vitamin A.

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